Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol [version 1; peer review: awaiting peer review]
Giri A, Karkey A, Dongol S et al. Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia: a randomised controlled trial protocol [version 1; peer review: awaiting peer review]. Wellcome Open Res 2021, 6:207
CLINICAL UPDATE: Enteric fever
Buddha Basnyat, Farah Naz Qamar, Priscilla Rupali, Tahmeed Ahmed, Christopher M Parry. BMJ 2021;372:n437. 26 February 2021
Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal
Mila Shakya, M.P.H.,Rachel Colin-Jones, M.A.,Katherine Theiss-Nyland, Ph.D.,Merryn Voysey, D.Phil.,Dikshya Pant, F.C.P.S.,Nicola Smith, M.B., B.Chir.,Xinxue Liu, Ph.D.,Susan Tonks, B.Sc., Olga Mazur, B.Sc.,Yama G. Farooq, M.Sc., Jenny Clarke, Ph.D., Jennifer Hill, Ph.D., et al., for the TyVAC Nepal Study Team*
Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial.
Arjyal A, Basnyat B, Nhan HT, Koirala S, Giri A, Joshi N, Shakya M, Pathak KR, Mahat SP, Prajapati SP, Adhikari N, Thapa R, Merson L, Gajurel D, Lamsal K, Lamsal D, Yadav BK, Shah G, Shrestha P, Dongol S, Karkey A, Thompson CN, Thieu NTV, Thanh DP, Baker S, Thwaites GE, Wolbers M, Dolecek C.Lancet Infect Dis. 2016 May;16(5):535-545. doi: 10.1016/S1473-3099(15)00530-7. Epub 2016 Jan 20.PMID: 26809813
A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes.
Manandhar S, Zellweger RM, Maharjan N, Dongol S, Prajapati KG, Thwaites G, Basnyat B, Dixit SM, Baker S, KarkeyA.AnnClinMicrobiolAntimicrob. 2020 Oct 21;19(1):48. doi: 10.1186/s12941-020-00390-y.PMID: 33087115
Gallbladder carriage generates genetic variation and genome degradation in Salmonella Typhi.
ThanhDuy P, Thieu NTV, Nguyen Thi Nguyen T, Ngoc Dan Thanh H, Dongol S, Karkey A, Carey M, Basnyat B, Dougan G, Rabaa MA, Baker S.PLoSPathog. 2020 Oct 21;16(10):e1008998. doi: 10.1371/journal.ppat.1008998. eCollection 2020 Oct.PMID: 33085725
Automating the Generation of Antimicrobial Resistance Surveillance Reports: Proof-of-Concept Study Involving Seven Hospitals in Seven Countries.
Lim C, Miliya T, Chansamouth V, Aung MT, Karkey A, Teparrukkul P, Rahul B, Lan NPH, Stelling J, Turner P, Ashley E, van Doorn HR, Lin HN, Ling C, Hinjoy S, Iamsirithaworn S, Dunachie S, Wangrangsimakul T, Hantrakun V, Schilling W, Yen LM, Tan LV, Hlaing HH, Mayxay M, Vongsouvath M, Basnyat B, Edgeworth J, Peacock SJ, Thwaites G, Day NP, Cooper BS, Limmathurotsakul D.J Med Internet Res. 2020 Oct 2;22(10):e19762. doi: 10.2196/19762.PMID: 33006570
Trimethoprim-sulfamethoxazole (SXT) versus azithromycin for the treatment of undifferentiated febrile illness in Nepal: a double-blind, randomized, placebo-controlled trial.
Giri A, Karkey A, Dangol S, Arjyal A, Pokharel S, Rijal S, Gajurel D, Sharma R, Lamsal K, Shrestha P, Prajapati G, Pathak S, Shrestha SR, K C RK, Pandey S, Thapa A, Shrestha N, Thapa RK, Poudyal B, Phuong DNT, Baker S, Kestelyn E, Geskus R, Thwaites G, BasnyatB.Clin Infect Dis. 2020 Sep 29:ciaa1489. doi: 10.1093/cid/ciaa1489. Online ahead of print.PMID: 32991678
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiellapneumoniae from South and Southeast Asia.
Wyres KL, Nguyen TNT, Lam MMC, Judd LM, van VinhChau N, Dance DAB, Ip M, Karkey A, Ling CL, Miliya T, Newton PN, Lan NPH, Sengduangphachanh A, Turner P, Veeraraghavan B, Vinh PV, Vongsouvath M, Thomson NR, Baker S, Holt KE.Genome Med. 2020 Jan 16;12(1):11. doi: 10.1186/s13073-019-0706-y.PMID: 31948471